Just because your snake is very docile, doesn't necessarily mean it enjoys being out. Even the most laid-back snakes will puff at being out sometimes. Sometimes it is just their way of letting you know they are not too happy, however it can also be a sign of the startings of an infection. I would watch for signs of your snake doing it while not being handled, and make sure your temps are warm enough (80/95) and humidity is at least 55%. Keep a close eye on things, and if you suspect it is something irrelevant to handling, it may be a good idea to have it checked out by an experienced reptile vet. Sometimes they undergo changes with age, etc. that may also contribute to such conditions, so even if it isn't related to handling, it may not be a problem, however it is always wise to rule out any possible problems first.
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