It's done a lot (unfortunately).
It's so hard to guarantee the locale of Panthers already, and that really sucks, so I would tend to stray away from doing it, but it's really up to you. If it's just a hobby and you don't plan on making a living off of chameleon breeding, then it's not really a big deal.
It will however make it so that you can't sell the offspring as locale specific animals such as Ambanja's, or Nosey Be's etc, but just as generic panthers, thus greatly reducing the value.
Just make sure whoever purchases the young is aware that they are not "pure" locale Panthers.
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