As for your snake associating you hand with food I believe this is jsut mroe of a train of thought people have than an actual truth. I used to at one time feed with a feeding container, but as my collection grew this became very inefficient and time consuming. Between work and my own observations at home, I have noticed absolutely no differences in behaviour from feeding in their enclosure. Agressive snakes have been tamed down fine, passive snakes have remained that way, nobody has become increasingly agressive. My conclusion is that it just creates more uneeded stress. As for putting substrate in a feeding box it is not necessary, and if you mean loose substrate, then that is highly inadvisable. Often people will utilize feeding boxes becasue the snake has loose substrate in its home, and feeding on it can result in an impaction. As long as your house isn't freezing, then all you need is a rubbermaid with a lid (unless you want to sit there and watch your snake and wait for him to finish).
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