I'm not sure exactly what you are asking. Did you wife feed an overly large prey item? If so, it may not affect your snake at all, on the other hand your snake may regurgitate the mouse back up. There isn't anything you can do now except wait and see what happens. Also, I wouldnt handle your snake for at least 4-5 days if he manages to keep the large meal down, a meal that size takes much longer to digest. If he regurgitates, leave him alone for AT LEAST 7 days (preferably 2 weeks) then offer him a small prey item (ie- pinky mouse). All you can do now is wait and see what happens, and make sure that something like this doesnt happen again. I hope everything works out