Are many small prey items worse than one big one?

[EL Ziggy]

I've had to feed multiple prey items when I had left over undersized feeders and I've never had any issues besides the small inconvenience of thawing and heating multiple mice vs. one rat. Also, an older retired jumbo breeder mouse will have more fat content than a younger, leaner rat weaner even though they'll both weigh about the same amount. Same for a medium mouse vs. a rat fuzzy. I'd rather give my snakes less fat and leaner meat if possible. Unfortunately my kings have been refusing rats lately but pounding down multiple mice and I haven't had the heart to starve them out until they accepted the switch . My bulls made the transition with no problems.