Some advice required.

[Toggsy]

First of all I'm not new to keeping snakes and I've kept them for a good few years so I'm not a novice or an inexperienced keeper but I've got a problem with a corn which is very concerning.
He's and adult anery male and is approx 5 years old normally he's the most placid, docile snake and you can do pretty much anything with him.
When he's in mood normally he will just rattle his tail and slope off into one of his hides and just poke his head out.
We offered him his food tonight as per normal, and normally he strikes and just gets on with in and if he's in one of his moods we just drop it in and leave him to it within 5 mins he's chomping it down.
Not tonight, we offered it to him he hissed and rattled his tail made a defensive strike, so my partner dropped the rat in the opposite end of his viv and but he struck at my partner whilst she was putting it in.
And since then he's watching every movement and striking at anything and everything including the glass.
Where he's striking at the glass and with so much force he's actually made his nose bleed in the process.
Whilst I want to get him out and check him over to make sure he's ok I feel where he's so agitated it will only make matters worse and stress him out even more.
I've managed to retrieve the food from his enclosure and I've covered his enclosure up with towels to stop him tracking any movements and I've turned the lights off in the enclosure.
I've checked the temps in the viv which were all are spot on and as they should be but I have turned the temps down to 24 in order to try and cool him down to make less active.
He's not due for shed as he only shed 3 weeks ago so I've ruled that out, and he's pooing ok so that can be ruled out.
I have noticed the last week or so he's been out cruising his enclosure more and is very very alert although we have had him out and he's been fine no aggressiveness and in fact he was out earlier in the day whilst we cleaned the enclosure out and replaced the temporary substrate.
We are treating our carpet pythons for mites and as a precaution we've treated all the other snakes in our collection including our corn wether or not they had them.
Before he was treated he was checked and found to mite free I'm using callingtons mite spray.
I've spoken to a fellow keeper who keeps and breeds corns and he seems to think it maybe down to fact he's ready to breed.

Just wanted to run it past everyone to get some other views on it.
At the moment he's not a happy bunny which is a concearn as normally he's a docile and pleasant snake.