It depends on the individual snake.
My Ball Python sometimes likes to roam late at night, and if I open the cage while he's roaming, sometimes he'll willingly come out to explore for a bit (he's very used to me). So I probably handle him twice a week.
My Carpet Python Spot would never strike at me, but he prefers it in his cage. He gets jumpy when pulling him out, and has a hard time relaxing outside of his cage. So I just pull him out every month or so for cage cleaning (and pictures
![Big Grin](http://www.ssnakess.com/forums/images/smilies/biggrin.gif)
).