why did my bp hiss at me ?? plz help

[skunk1]

ok today my bp hissed at me she has never ever done this to me i didnt even know they did that till today . i have had her for two years . she has neverr done this . i was taking her cave out and gonna take her out like i always do and as soon as i touched her she hissed so i tryed to pick her up again and she did it again? i handle her every week . she never got aggreisive or curled up . it just kinda freaked me out ?? should i be worried? help?