How bout working on switching to rats? The earlier you do this, the better it will be. Ball Pythons can be pain in the butt feeders

Until then, yes you can just leave the two mice in her cage overnight, just like you would one

When you go away, make sure she has a clean dish of water and her temps are stable. Leaving her night light on if is fine as long as it provides proper daytime temps. She looks fine in the ten for now as well. Have fun on your trip